COVID-19 patients can recover within three days with antibody cocktail: AIG Hospitals

Monoclonal antibodies-based treatment is seen as the latest armament in the fight against COVID-19. The antibody cocktail has gained enough traction from global media ever since it got administered on ex-US president Donald Trump.

Hyderabad-based AIG Hospitals on May 27 hosted a virtual conference highlighting the benefits of the treatment. Dr D Nageshwar Reddy, chairman at the hospital, demystified some of the most asked questions regarding the therapy.

Reddy said that the real-world evidence of these monoclonal antibodies is yet to be established but the clinical studies published in peer-reviewed journals including the New England Journal of Medicine are encouraging as they have shown to reduce hospitalization or death by over 70%, including a drastic reduction in viral clearance.

In this context, Reddy added that the timing and patient selection becomes extremely important. “Patients over 65, obese with uncontrolled diabetes, cardiovascular patients, those who are under immunosuppressants like cancer patients are ideal candidates for this treatment. The timing also has to be appropriate where it needs to be given within three to seven days at max,” Reddy said. This can be given to patients above 55 if they have heart-related issues like hypertension.

He further added: “Within one week, antibody cocktail can help patients become RT-PCR negative. Pregnant women are not supposed to be given this treatment as we don’t have enough safety data for this subset of patients. There is also a possibility to explore the prophylactic usage of this combination especially among the high-exposure groups like healthcare workers. This to be highlighted that as per US FDA, benefits of this antibodies cocktail have not been observed in patients hospitalized due to COVID-19; moreover, if this combination is administered on patients requiring high-flow oxygen or mechanical ventilation then the clinical outcomes can become worse.”

“Let us understand a bit about how Monoclonal Antibodies work. They bind to the spike proteins of the virus (S1 and S2) and thereby limiting its replication. Mutation in the virus can impact the effectiveness of this monoclonal antibodies’ treatment. Although the effectiveness against some of the variants have been proven, we are not sure about how it will go against the double mutant B.1.617, the so-called Indian variant. At AIG Hospitals, we are doing a major study where we are looking at its efficacy against the double mutant variant of the virus,” Reddy said.

He further added that “antibody cocktail has the potential to increase mutant variants and that is why irrational use of these antibodies’ cocktails should be absolutely discouraged.”

Once administered with the antibody cocktail, patients should wait for at least three months before getting vaccinated. One of the most crucial aspects of the therapy is the cost factor especially in low-middle income countries like India, where the treatment cost is around Rs 70,000. “Hospitals and physicians need to factor in this cost element for its judicial usage,” Reddy said.

The antibody cocktail therapy is to be given only in a hospital setting where there is provision to activate the emergency medical system immediately following any infusion-related adverse reaction.

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